Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood move in males with established coronary artery illness . Therefore, an interplay of endogenous factors of the patient’s threat profile in addition to the testosterone dosing could also be problems with whether or not opposed occasions occur. Erythrocytosis has been reported as a potential impact of testosterone, which could be helpful in patients with anemia. The best risk of erythrocytosis occurs with injectable types of testosterone compared with transdermal preparations, especially in supraphysiologic doses. An improve of as a lot as 44% of the baseline hematocrit has been reported . Moreover, testosterone has been used within the remedy of reduced muscle mass and bone density as well as anemia. The role testosterone may play in the improvement of cardiovascular disease has more and more turn out to be the subject of current interest .
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- However, testosterone in physiologic doses might even be useful in sufferers with angina , have larger ischemic thresholds and improved quality of life .
- Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in men with established coronary artery disease .
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Relationship between endogenous intercourse hormone levels, lipoproteins and coronary atherosclerosis in men present process coronary angiography. Basaria S, Dobs AS. Risks versus advantages of testosterone therapy in aged males. Scientific and technological providers and analysis and design relating thereto; industrial analysis and analysis companies; design and growth of computer hardware and software program.
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac risk components utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, probably secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the best coronary artery. Physicians and patients should be conscious of the medical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity. However, testosterone in physiologic doses might even be beneficial in sufferers with angina , have greater ischemic thresholds and improved high quality of life .
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