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- The role testosterone could play within the improvement of cardiovascular disease has more and more turn out to be the subject of current curiosity .
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- They proceed to be used by Olympic stage athletes, and have even unfold to high school stage athletes, noncompetitive bodybuilders and recreational athletes (Sullivan et al 1998; Dhar et al 2007).
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with conventional cardiac threat components using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person additionally had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the best coronary artery. Physicians and sufferers should pay attention to the scientific consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity.
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Patients also could additionally be taking concomitant stimulants, such as ephedra, which may confound knowledge and the potential for opposed events. It is likely that the frequency of cardiac events is underreported within the medical literature. Moreover, testosterone has been used in the remedy of reduced muscle mass and bone density in addition to anemia. The position testosterone may play within the growth of heart problems has more and more turn into the topic of current curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embody more than 30 natural and artificial derivatives of testosterone, might cause a wide spectrum of medical sequalae. Supplemental or physiologic doses of testosterone have observed expanded use in medical practice just lately. Other common potential antagonistic effects embrace infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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However, testosterone in physiologic doses could even be helpful in patients with angina , have greater ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood flow in men with established coronary artery disease . Therefore, an interplay of endogenous components of the patient’s threat profile as properly as the testosterone dosing may be problems with whether or not antagonistic events occur. Erythrocytosis has been reported as a potential impact of testosterone, which could be helpful in patients with anemia.
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